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If you are taking this drug to prevent stomach ulcerstake it by mouth usually four times a dayafter meals and at bedtime to minimize diarrheaor as directed by your doctor.

Pharmacokinetic studies also showed a lack of drug interaction with antipyrine and propranolol when these drugs were given with misoprostolMisoprostol given for 1 week had no effect on the steady state pharmacokinetics of diazepam when the two drugs were administered 2 hours apart.

Approximately a 3-fold increased risk of malformations was reported in pregnancies exposed to misoprostol during the first trimestercompared to a control group incidence of 2In particularprenatal exposure to misoprostol has been associated with Moebius syndromecongenital facial paralysis leading to hypomimiatroubles of suckling and deglutition and eye movementswith or without limb defectsamniotic band syndromelimb deformitiesamputationsespecially clubfootacheiriaolygodactylycleft palate inter aliaand central nervous system anomaliescerebral and cranial anomalies as anencephalyhydrocephalycerebellar hypoplasianeural tube defectsOther defects including arthrogryposis have been observed.

Can cause birth defectsabortionpremature birth or uterine rupture in pregnant womenFor women of childbearing potentialnegative serum pregnancy test within 2 weeks before starting therapybegin on 2 nd or 3 rd day of next menstrual periodmaintain contraception during therapygive oral and written warnings on risks in pregnancyCardiovascular diseaseInflammatory bowel diseaseDehydrationLabordeliveryNursing mothers.

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