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Mao inhibitors within 14 days – serious, even fatal interactions can occur when taken with tegretol alcohol – when taken with tegretol can dangerously lower blood pressure seldane terfenadine , prozac fluoxetine , luvox fluvoxamine , and rifampin – can lead to drug toxicity tranquilizers, hypnotics, and narcotics – tegretol can increase the effects of these drugs adrenocortical steroids, antidepressants, birth control pills, sandimmune cyclosporine , doxy-ii and vibramycin doxycycline , plendil felodipine , haldol haloperidol , dynacirc isradipine , sporanox itraconazole , tetracyclines, depakene valproic acid , and coumadin warfarin – tegretol can decrease the effects of these drugs clozaril clozapine – can cause serious bone marrow suppression when taken with tegretol felbatol felbamate – can reduce the body s levels of tegretol lithium – taken with tegretol can cause neurological problems such as confusion, tremors, and weakness dilanin phenytoin – can impair seizure control due to fluctuation of blood levels theo-dur theophylline – when taken with tegretol, the effects of both of these drugs can decrease tagamet cimetidine , danocrine danazol , cardizem diltiazem , flu shots, inh isoniazid , erythromycin and other macrolide antibiotics, nicotinamide, darvon propoxyphene , norvir ritonavir , and calan isoptin verapamil – these drugs may increase the effects of tegretol phenobarbital and biaxin clarithromycin – can increase the toxicity of tegretol.

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Many drugs can interact with clozapineNot all possible interactions are listed hereTell your doctor about all your current medicines and any you start or stop usingespecially:

Headache with chest pain and severe dizzinesspounding heartbeats or fluttering in your chest;

As with other antipsychoticscaution should be exercised when clozapine is prescribed with medicines known to increase QTc intervalor causing electrolyte imbalance.

Since Clozaril may be associated with thromboembolismimmobilisation of patients should be avoided.

Patients who have low WBC counts because of benign ethnic neutropenia should be given special consideration and may only be started on Clozaril with the agreement of a haematologist.

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