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۴Schellhammer PSharifi RBlock NSoloway MVenner PPatterson ALSarosdy MVogelzang NJones JKolvenbag GA controlled trial of bicalutamide versus flutamideeach in combination with luteinizing hormone-releasing hormone analogue therapyin patients with advanced prostate cancerCasodex Combination Study GroupUrology 451995745-52.

Hepatic side effects including severe liver injury leading to hospitalization and death have been reported rarelyHepatitis or marked increases in liver enzymes leading to drug discontinuation have been reported in approximately 1of bicalutamide patientsOne case of fulminant hepatic failure associated with bicalutamide use has also been reportedRef]

Casodex may impair your thinking or reactionsBe careful if you drive or do anything that requires you to be alert.

Use this medication regularly to get the most benefit from itTo help you remembertake it at the same time each day.

HepatitisInform patients that Casodex can cause hepatitiswhich may result in hepatic failure and deathAdvise patients that liver function tests should be monitored regularly during treatment and to report signs and symptoms of hepatitissee Warnings and Precautions5.1

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